Polypeptide inhibitors of protein farnesyl transferase

摘要

Inhibitors of protein farnesyl transferase enzymes of formula (I), wherein R1, R2, R4 & R21 are independently selected from hydrogen and alkyl, RQ is a 4-alkyleneimidazole group optionally substituted with an alkyl group on either nitrogen atom, A is -CORa, -CONHRa, -CSRa, -C(O)SRa, -C(S)ORa, -C(S)NHRa, -SO2Ra, -CONRa2 or -C(S)NRa2, wherein each Ra is independently selected from alkyl, cycloalkylalkyl, arylalkyl and heteroarylalkyl, R3 is selected from alkyl and optionally substituted cycloalkylalkyl, arylalkyl and heteroarylalkyl and R5 is an optionally substituted C2-C3 alkylene (optionally containing an oxygen atom) terminated with one or two aryl or heteroaryl groups. The compounds are useful in treating cancer, restenosis, psoriasis, endometriosis, atherosclerosis, or viral infections.