| 摘要 |
A photosensitive compound called texaphyrin and shown for the photodynamic treatment of a pigmented lesion, such as a melanodermic lesion, or of a lesion obscured by pigmented tissue, such as melaniferous tissue in a subject. It provides a treatment for the metastatic process of melanoma, and a method for inhibiting growth of established metastases of melanoma. The photosensitive texaphyrin may be a free-base texaphyrin or may be metallated with a diamagnetic metal. Preferably, the texaphyrin is metallated with lutetium. Wherein; M is a diamagnetic metal cation; R1-R4, R7 and R8 are independently hydrogen, halide, hydroxyl, alkyl, alkenyl, alkynyl, aryl, haloalkyl, nitro, formyl, acyl, hydroxyalkyl, alkoxy, hydroxyalkoxy, hydroxyalkenyl, hydroxyalkynyl, saccharide, carboxy, carboxyalkyl, carboxyamide, carboxyamidealkyl, amino, aminoalkyl, a site-directing molecule, a catalytic group, or a couple that is coupled to a site-directing molecule or to a catalytic group; R6 and R9 are independently selected from the groups of R1-R4, R7 and R8, the proviso that the halide is other than iodide and the haloalkyl is other than iodoalkyl; R5 and R10-R12 are independently hydrogen, alkyl, alkenyl, alkynyl, aryl, hydroxyalkyl, alkoxy, hydroxyalkoxy, hydroxyalkenyl, hydroxyalkynyl, carboxyalkyl, carboxyamide, carboxyamidealkyl, amino, aminoalkyl, or a couple that is coupled to saccharide, to a catalytic group, or to a site-directing molecule; and n is an integer values less than or equaled 5.
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