Synthesis of long chain polyunsaturated fatty acids, omega-3 and omega-6 fatty acids, specifically eicosapentaenoic acid and arachidonic acid

摘要

Fatty acid desaturases able to catalyze the conversion of oleic acid to linoleic acid, linoleic acid to gamma-linolenic acid, or of alpha-linolenic acid to stearidonic acid. Nucleic acid sequences encoding fatty acid desaturases, DNA constructs comprising a desaturase gene, and recombinant host microorganism or animal expressing increased levels of a desaturase is described. Methods for desaturating a fatty acid and for producing a desaturated fatty acid by expressing increased levels of a desaturase are disclosed. Fatty acids, and oils containing them, which have been desaturated by a desaturase produced by recombinant host microorganisms or animals are provided. Pharmaceutical compositions, infant formulas or dietary supplements containing fatty acids which have been desaturated by a desaturase produced by a recombinant host microorganism or animal also are described.