发明名称 |
METHODS FOR THE PREVENTION AND TREATMENT OF DISEASES CAUSED BY AN INFLAMMATORY RESPONSE MEDIATED BY ENDOGENOUS SUBSTANCE P BY USING ANTI-SUBSTANCE P ANTIBODIES |
摘要 |
The present invention provides methods for preventing or treating a disease in a subject which is caused by an inflammatory response to a disease or syndrome which is mediated by endogenous substance P. These methods comprise the administration to the subject of a pharmaceutically-effective amount of anti-substance P antibodies, or anti-substance P antibody fragments, such as F(ab)2 fragments, thereby inhibiting the activity of endogenous substance P in the subject. By inhititing the activity of endogenous substance P in the subject, the levels of cytokines produced by T lymphocytes present in the subject are reduced, the signals which direct the inflammatory response to the infection become altered, and the amount of cytokine-induced inflammation becomes reduced. Respiratory syncytial virus is one example of an agent which causes an infection which often results in a disease caused by an inflammatory response to the infection mediated by endogenous substance P. Generally, from about 0.001 mg to about 10 g of anti-substance P antibodies, or anti-substance P antibody fragments, per kilogram of body weight per day are administered to a mammalian subject, with from about 1 mg to about 1000 mg of anti-substance P antibodies, or anti-substance P antibody fragments, per kilogram of body weight per day being preferred.
|
申请公布号 |
WO0043040(A1) |
申请公布日期 |
2000.07.27 |
申请号 |
WO2000US01032 |
申请日期 |
2000.01.14 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES;TRIPP, RALPH, A.;ANDERSON, LARRY, J.;MOORE, DEBORAH, D. |
发明人 |
TRIPP, RALPH, A.;ANDERSON, LARRY, J.;MOORE, DEBORAH, D. |
分类号 |
A61P29/00;A61P31/00;C07K16/18;C07K16/26;(IPC1-7):A61K39/395;A61P1/00;A61P11/00;A61P19/00;A61P37/00 |
主分类号 |
A61P29/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|