METHOD FOR PRODUCING L-PHENYLEPHRINE HYDROCHLORIDE

摘要

The invention relates to an improved method for the industrial-scale production of L-phenylephrine hydrochloride 3 by asymmetric hydrogenation as key step and a special series of subsequent steps. According to the invention [Rh(COD)Cl]2 is used as catalyst and a chiral, bidentate phosphine ligand such as (2R, 4R)-4-(dicyclohexylphospino)-2-(diphenylphosphino-methyl)-N-methyl-aminocarbonyl-pyrrolidine is used as catalyst system.