STABILISATION OF COMPOSITIONS COMPRISING NON-VIRAL NUCLEIC ACID TRANSFER COMPOSITIONS

摘要

The present invention relates to a method for preparing a storage-stable and/or transportable cell-delivery nucleic acid composition comprising preparing an aqueous solution comprising said nucleic acid and, optionally, at least one cationic polymer. Further, the invention relates to a method for preparing a storage-stable and/or transportable cell-delivery nucleic acid composition without the need for cryopreserving and/or lyopreserving the composition. In a further aspect, the invention relates to a method for preparing a cell-delivery nucleic acid composition comprising preparing an aqueous solution comprising said nucleic acid and, optionally, at least one cationic polymer, and, before use, storing said solution for at least 2 weeks at a temperature between 0 DEG C and approximately the denaturation temperature of said nucleic acid in said solution, preferably at a temperature between 0 DEG C and approximately 40 DEG C. In addition, the storable products of these methods, as weel as the use of the stabilising compounds are part of the present invention.