发明名称 STABILISATION OF COMPOSITIONS COMPRISING NON-VIRAL NUCLEIC ACID TRANSFER COMPOSITIONS
摘要 <p>The present invention relates to a method for preparing a storage-stable and/or transportable cell-delivery nucleic acid composition comprising preparing an aqueous solution comprising said nucleic acid and, optionally, at least one cationic polymer. Further, the invention relates to a method for preparing a storage-stable and/or transportable cell-delivery nucleic acid composition without the need for cryopreserving and/or lyopreserving the composition. In a further aspect, the invention relates to a method for preparing a cell-delivery nucleic acid composition comprising preparing an aqueous solution comprising said nucleic acid and, optionally, at least one cationic polymer, and, before use, storing said solution for at least 2 weeks at a temperature between 0 °C and approximately the denaturation temperature of said nucleic acid in said solution, preferably at a temperature between 0 °C and approximately 40 °C. In addition, the storable products of these methods, as weel as the use of the stabilising compounds are part of the present invention.</p>
申请公布号 WO2000043530(A2) 申请公布日期 2000.07.27
申请号 NL2000000046 申请日期 2000.01.21
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