发明名称 A process for the preparation of pyridine dicarboxylate derivaties.
摘要 Single vessel preparation of pyridine dicarboxylate comprises sequential condensation of alkyl vinyl ether and Vilsmeier reagent, oxalacetate and ammonia. Preparation of substituted pyridine derivatives of formula (I) comprises: (a) reacting an alkyl vinyl ether derivative of formula (II) with at least one molar equivalent of Vilsmeier reagent optionally in the presence of a first solvent to form a first intermediate; (b) reacting with at least one molar equivalent oxalacetate derivative of formula (III) in the presence of at least two molar equivalents of an organic amine base to form a second intermediate; and (c) reacting with an ammonia source optionally in the presence of a second solvent to form (I). [Image] R 1H or 1-4C alkyl (optionally substituted by 1-4C alkoxy or halo); R 2, R 31-6C alkyl; and R : 1-4C alkyl.
申请公布号 ZA9900615(B) 申请公布日期 2000.07.27
申请号 ZA19990000615 申请日期 1999.01.27
申请人 AMERICAN CYANAMID COMPANY 发明人 ROBERT FRANCIS DOEHNER JNR.
分类号 C07D213/803;C07B43/00;C07D213/79;C07D213/80 主分类号 C07D213/803
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