发明名称 |
HIV-1 MUTATIONS SELECTED FOR BY .BETA.-2',3'-DIDEHYDRO-2',3'-DIDEOXY-5-FLUOROCYTIDINE |
摘要 |
The present invention discloses a method for treating HIV that includes administering .beta.-D-D4FC or its pharmaceutically acceptable salt or prodr ug to a human in need of therapy in combination or alternation with a drug that induces a mutation in HIV-1 at a location other than the 70(K to N), 90 or t he 172 codons of the reverse transcriptase region. Also disclosed is a method f or using .beta.-D-D4FC as "salvage therapy" to patients which exhibit drug resistance to other anti-HIV agents. .beta.-D-D4FC can be used generally as salvage therapy for any patient which exhibits resistance to a drug that induces a mutation at other than the 70(K to N), 90 or the 172 codons.</SDOA B>
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申请公布号 |
CA2360039(A1) |
申请公布日期 |
2000.07.27 |
申请号 |
CA20002360039 |
申请日期 |
2000.01.21 |
申请人 |
EMORY UNIVERSITY |
发明人 |
SCHINAZI, RAYMOND F.;MELLORS, JOHN W.;LIOTTA, DENNIS C.;HAMMOND, JENNIFER L. |
分类号 |
C12N15/01;A61K31/513;A61K31/70;A61K31/7068;A61K45/00;A61K45/06;A61P31/18;(IPC1-7):A61K31/513 |
主分类号 |
C12N15/01 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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