| 摘要 |
<p>A process for producing compounds (II-a) or compounds (II-b), which are respectively hydroxylated products of compounds represented by general formula (I-a) (here in after referred to as the compounds (I-a)) or closed lactone derivatives thereof (hereinafter referred to as the compounds (I-b)). In formula (I-a) R1 represents hydrogen, optionally substituted alkyl or an alkali metal; and R2 represents optionally substituted alkyl or optionally substituted aryl. This process is characterized by treating in an aqueous medium the compounds (I-a) or (I-b) with an enzyme source comprising a microorganism having an activity of hydroxylating the compounds (I-a) or (I-b), having no sporulability and showing no hyphal growth, or an optionally processed culture of the microorganism and collecting the compounds (II-a) or (II-b) from the aqueous medium.</p> |
