SUBSTITUTED NITROGEN HETEROCYCLIC DERIVATIVES AND PHARMACEUTICAL USE THEREOF

摘要

This invention relates to new substituted nitrogen heterocyclic derivatives having cytostatic, anticancer, antimitotic, antineurogenerative, immunosuppressive and antimicrobial effects. This invention also relates to the methods for preparation of these derivatives, the use of the compounds as drugs, the pharmaceutical composition and combined pharmaceutical application form comprising an effective dose of a claimed compound and the use of these derivatives for drug production.