发明名称 |
PARENTERAL METOLAZONE FORMULATIONS |
摘要 |
The invention provides a method of making a pharmaceutical composition comprising a solution, which method comprises: (a) providing a solvent comprising propylene glycol, polyethylene glycol, polypropylene glycol, or glycerin; and (b) adding metolazone. The final concentration of metolazone in the solution is 9 mg/ml or more, the metolazone is not precipitated, and the concentration of metolazone is above its apparent equilibrium solubility. The invention also provides a pharmaceutical composition comprising a solution comprising: (a) a solvent other than water; and (b) 9 mg/ml or more of metolazone. The metolazone is not precipitated in this solution and the concentration of metolazone is above its apparent equilibrium solubility.
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申请公布号 |
WO0043042(A1) |
申请公布日期 |
2000.07.27 |
申请号 |
WO2000US01682 |
申请日期 |
2000.01.21 |
申请人 |
MEDEVA PHARMACEUTICALS MANUFACTURING, INC. |
发明人 |
SANTELLI, RONALD;TU, YU-HSING |
分类号 |
A61K9/00;A61K31/517;A61K47/10;A61P7/10;A61P9/12;(IPC1-7):A61K47/10 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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