发明名称 |
COMPLEX OF RAS-FARNESYLTRANSFERASE INHIBITOR AND SULFOBUTYLETHER-7- beta -CYCLODEXTRIN OR 2-HYDROXYPROPYL- beta -CYCLODEXTRIN AND METHOD |
摘要 |
A ras-farnesyltransferase inhibitor complex formed of ras-farnesyltransferase inhibitor or a pharmaceutically acceptable salt thereof, of formula (I), wherein n is 0 or 1; R1 is selected from Cl, Br, phenyl, pyridyl or cyano; R2 is aralkyl; R3 is selected from lower alkyl, aryl or substituted aryl or heterocyclo; Z1 is selected from CO, SO2, CO2 or SO2NR5, R5 is selected from hydrogen, lower alkyl or substituted alkyl; and sulfobutylether-7- beta -cyclodextrin or 2-hydroxypropyl- beta -cyclodextrin is provided. The complex has unexpectedly high aqueous solubility of the ras-farnesyltransferase inhibitor and is useful for its intravenous delivery to humans with cancer. Also provided is a method for forming the complex. The ras-farnesyltransferase inhibitors are useful as anti-tumor agents.
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申请公布号 |
WO0042849(A1) |
申请公布日期 |
2000.07.27 |
申请号 |
WO1999US30424 |
申请日期 |
1999.12.21 |
申请人 |
BRISTOL-MYERS SQUIBB CO. |
发明人 |
RAGHAVAN, KRISHNASWAMY, S.;MALLOY, TIMOTHY, M.;VARIA, SAILESH, A. |
分类号 |
C07D403/06;A61K9/08;A61K31/55;A61K31/5513;A61K47/12;A61K47/40;A61K47/48;A61P35/00;C07D243/14;C07D409/14;(IPC1-7):A01N43/00 |
主分类号 |
C07D403/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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