发明名称 2-PIPERAZINO ALKYLAMINO BENZOAZOLE DERIVATIVES: DOPAMINE RECEPTOR SUBTYPE SPECIFIC LIGANDS
摘要 Disclosed are compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein: A is (un)substituted alkylene; R1 and R2 are the same or different and represent hydrogen, halogen, alkyl, alkoxy, alkylthio, hydroxy, (un)substituted amino, cyano, nitro, sulfonamide, trifluoromethyl or trifluoromethoxy; R3, R4, R5, R6 and R8 are independently hydrogen or alkyl; and X is sulfur, oxygen or NR7 where R8 is defined herein; m is an integer chosen from 0, 1 or 2; and Ar is an aryl or heteroaryl group as further defined herein, which compounds are useful for the treatment and/or prevention of neuropsychological disorders including, but not limited to, schizophrenia, mania, dementia, depression, anxiety, compulsive behavior, substance abuse, Parkinson-like motor disorders and motion disorders related to the use of neuroleptic agents.
申请公布号 WO0018767(A3) 申请公布日期 2000.07.27
申请号 WO1999US22791 申请日期 1999.09.30
申请人 NEUROGEN CORPORATION;HE, XIAO-SHU 发明人 HE, XIAO-SHU
分类号 C07D277/82;A61K31/495;A61K31/496;A61K31/506;A61P25/16;A61P25/18;A61P25/22;A61P25/24;A61P25/28;A61P25/30;C07D209/48;C07D235/30;C07D263/58;C07D401/12;C07D403/12;C07D413/12;C07D417/12;C07D419/12;(IPC1-7):C07D419/12 主分类号 C07D277/82
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