| 摘要 |
PURPOSE: Provided are methods for killing antibiotic-resistant pathogenic bacteria which cause disease in humans and animals. In particular, the methods are directed to the killing of antibiotic-resistant or multi-drug resistant Streptococcus pneumoniae bacterial strains. The methods employ a lanthocin such as nisin or a variant thereof as bactericidal agent. CONSTITUTION: A method for killing antibiotic-resistant or multidrug-resistant pathogenic bacterial strains of StrePtococcus Dneumoniae, which comprises administering to a mammal in need of such treatment in an amount ranging from about 0.078 mg/kg/dose to about 20 mg/kg/dose of a lanthocin antimicrobial, or an analog thereof which is also effective against S. pneumoniae, in excess of its minimal inhibitory concentration.
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