| 摘要 |
PURPOSE: A preparation of new corticoid compounds is provided which is steroid-structured compounds having anti-inflammatory, immunodepressive and angiostatic activities (the so-called steroid anti-inflammatory drugs). CONSTITUTION: Compounds of the general formula B-X1-NO2 or their esters or salts are present;:where B has structure (1) where there are substituents in place of the hydrogens H in the CH group or two hydrogens H2 in the CH2 group shown in the general formula; R and R' are equal or different one from the other and are rogen or linear or branched alkyls having from 1 to 4 carbon atoms, preferably R = R' = CH3; B being a corticosteroid residue; R'' is -(CO-L)t-(X)t1- where t and t1 are integers equal or different one from the other and equal to 0 or 1; where L is a bivalent connecting group; X is equal to X0 where X0 = 0, NH, NR1C where R1C is a linear or branched alkyl having from 1 to 10 C atoms; or equal to X2 where X2 is equal to OH, CH3, Cl, N(-CH2-CH3)2, SCH2F, SH; X1 is a bivalent connecting bridge YO where Y is a C1-C20 alkylene.
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