| 摘要 |
PURPOSE: Provided are novel substituted tricyclic organic compounds useful for inhibiting sPLA2 mediated release of fatty acids for conditions such as septic shock. CONSTITUTION: Provided are tricyclic compounds as depicted in the general formula (III) wherein; A is phenyl or pyridyl wherein the nitrogen is at the 5-,6-,7- or 8-position; one of B or D is nitrogen and the other is carbon; Z is cyclohexenyl, phenyl, pyridyl, wherein the nitrogen is at the 1-,2-, or 3-position, or a 6 membered heterocyclic ring having one heteroatom selected from the group consisting of sulfur or oxygen at the 1-,2-,or 3-position, and nitrogen at the 1-,2-,3- or 4-position, which inhibit sPLA2 mediated release of fatty acids (e.g. arachidonic acid). Such compounds would be of value in general treatment of conditions induced and/or maintained by overproduction of sPLA2 such as septic shock.
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