| 摘要 |
PURPOSE: N-substituted azaheterocyclic compounds are provided which are useful for the treatment, prevention, elimination, alleviation or amelioration of an indication related to all painful, hyperalgesic and/or inflammatory conditions in which C-fibres play a pathophysiological role, e.g. neurogenic pain, inflammation, migraine, neuropathy, itching and rheumatoid arthritis, as well as indications caused by or related to the secretion and circulation of insulin antagonizing peptides, e.g. non-insulin-dependent diabetes mellitus (NIDDM) and ageing-associated obesity. CONSTITUTION: Novel N-substituted azaheterocyclic carboxylic acids of formula I are provided, wherein R1 and R2 independently are hydrogen, halogen or C1-6 -alkyl; and Y is >N-CH2- or >C=CH- wherein only the underscored atom participates in the ring system; and X is -S-, -CH2CH2-, -O-CH2-, -CH2-O-, -S-CH2-, -CH2-S-; and r is 1 or 2; and Z is selected from wherein R3 is -(CH2)pCOOH wherein p is 0 or 1.
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