| 摘要 |
The present invention relates to an process for the preparation of ibuprofen, which comprises reacting para isobutyl phenylethanol (p-IBPE), a halide source, a protonic acid, water and the catalyst which is a compound having formula 1 which is shown herebelow: Wherein M = a group VIII metal specifically palladium or platinum, R1, R2, R3 = substituents on the phosphine ligand such as hydrogen, alkyl, aryl, arylalkyl cycloaliphatic, X = groups such as aryl or alkyl sulphonato or aryl or alkyl carboxylato ort formato or halides such as CI-, Br-, I-, = a semilabile anionic chelating ligand containing a donor and an O-group such as 8-hydroxy quinoline, 2-hydroxy pyridine, 2-(2-hydroxy ethyl)pyridine, pyridyl-2-, piperidyl-2-, quinolyl-2-, isoquinolyl-1- and isoquinolyl-3- carboxylates, particularly pyridyl-2-carboxylate, piperidyl-2-carboxylate, and 8-hydroxyquinoline, 1<n<10 in an organic solvent under constant stirring in carbon monoxide atmosphere under biphasic or homogeneous conditions, at a temperature ranging between 30 to 130 DEG C., for a period ranging between 0.3 to 6 hrs, at pressure ranging between 50 to 1500 psig, cooling the reaction mixture to ambient temperature, flushing the reaction vessel with inert gas, removing the solvent by conventional methods, separating the catalyst and isolating the product.
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