| 摘要 |
PURPOSE: Novel pharmaceutical compounds, and in particular to substituted polyamines containing at least 2 electron-affinic groups, methods of preparing these compounds, and methods of using these compounds in various pharmaceutical applications such as in treating diseases caused by anaerobic and microaerophilic microorganisms and in radiosensitizing hypoxic tumor cells, are provided. CONSTITUTION: A polyamine compound has the structure of formula 1, wherein: A is a spacer comprising a chain having at least 2 atoms in the chain, the chain being other than hydrocarbon; R1 is hydrogen, hydrocarbon, heterosubstituted hydrocarbon, heteroaryl, heterosubstituted heteroaryl, or -L-(EAG)a; R2 is hydrogen, hydrocarbon, heterosubstituted hydrocarbon, heteroaryl, heterosubstituted heteroaryl, or -L-(EAG)b; R3 is hydrogen, hydrocarbon, heterosubstituted hydrocarbon, heteroaryl, heterosubstituted heteroaryl, or -L-(EAG)C; R4 is hydrogen, hydrocarbon, heterosubstituted hydrocarbon, heteroaryl, heterosubstituted heteroaryl, or -L-(EAG) d; each L is independently a linker comprising a linker chain having at least 1 atom in the chain; a, b, c, and d are each independently an integer not less than zero, with the sum of a, b, c, and d being not less than 2; each EAG is independently an electron-affinic group; and the compound or salt contains at least one tertiary amine functionality having three substituents each of which independently contain at least one electron-affinic group or hydrophilic group.
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