INHIBITION OF ERYTHROCYTE SICKLING BY N-L-ALPHA-ASPARTYL-L-PHENYLALANINE 1-METHYL ESTER

摘要

It has now been found that N-L-alpha-aspartyl-L-phenylalanine 1-methyl ester (APM) exhibits antisickling properties. In vitro testing verified that APM significantly lowered the frequency of sickling of red blood cells from each of twelve pediatric aged patients being treated for sickle-cell anemia by exchange transfusion. Sickling was also inhibited in an "index" patient after oral administration of APM. These in vitro and in vivo results identify APM as a therapeutic agent for the family of sickle cell molecular diseases.