| 摘要 |
A compound of formula (I), wherein NRR1 is attached at the 5- or 6-position of the furopyridine ring; R is hydrogen, C1-C4 alkyl, or COR2; R1 is (CH2)nAr, CH2CH=CHAr, or CH2C~CAr; n is 0 to 3; A is N or NO; Ar is a 5- or 6-membered aromatic or heteroaromatic ring which contains zero to four nitrogen atoms, zero to one oxygen atoms, and zero to one sulfur atoms; or an 8-, 9- or 10- membered fused aromatic or heteroaromatic ring system containing zero to fou r nitrogen atoms, zero to one oxygen atoms, and zero to one sulfur, any of whi ch may optionally be substituted with one to two substituents independently selected from: halogen, trifluoromethyl, or C1-C4 alkyl; R2 is hydrogen, C1- C4 alkyl, C1-C4 alkoxy or phenyl ring optionally substituted with one to three of the following substituents: halogen, C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, OH; OC1-C4 alkyl, CO2R5, -CN, -NO2, -NR3R4, or -CF3; R3, R4 and R5 may be hydrogen, C1-C4 alkyl, or phenyl ring optionally substituted with one to three of the following substituents: halogen, C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, OH; OC1-C4 alkyl, -CN, -NO2, or -CF3; and enantiomers thereof , and pharmaceutically acceptable salts thereof, processes for preparing them, composition containing them, and their use in therapy, especially in the treatmentor prophylaxis of psychotic disorders and intellectual impairment disorders.
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