| 摘要 |
organic chemistry, pharmacy. SUBSTANCE: invention relates to compounds of the formula (I) and their pharmaceutically acceptable salts where substitute R means halogen-C1-C8-alkyl, halogen-C2-C8-alkenyl, halogen-C2-C8-alkynyl or halogen-C1-C8-alkyl substituted with hydroxy- or C1-C8-alkoxy-group; R1 means hydrogen atom, halogen atom or C1-C8-alkoxy-group; or R and R1 in common with two carbon atoms that are common for benzene ring form condensed C4-C6-cycloalkyl where one carbon atom is optionally replaced for oxygen atom and where one or two carbon atoms have optionally up to five substituents taken among: halogen atom, C1-C6-alkyl and halogen-C1-C6-alkyl; X means C1-C6-alkoxy-, halogen-C1-C6-alkoxy-, phenoxy-group or halogen atom; Ar means phenyl group optionally substituted with halogen atom. These compounds can be used for treatment of gastroenteric disorder, central nervous system disorder, inflammatory disease, vomiting and others. EFFECT: valuable medicinal properties of compounds. 20 cl, 4 tbl, 21 ex |
