METHODS FOR INHIBITING TUMOR METASTASIS, AND PEPTIDES USEFUL THEREFOR

摘要

In accordance with the present invention, there are provided peptides that bind to a member of the mammalian selectin family and inhibit the binding of a carbohydrate to the selectin. Invention peptides are useful to inhibit the adhesion of cells containing particular cell-surface carbohydrates to cells containing cell-surface selectins. Also provided are pharmaceutical compositions comprising invention peptides useful in methods for inhibiting a carbohydrate from binding to a selectin, and in methods of inhibiting tumor cell metastasis in a subject.