发明名称 |
PARTICLES FOR ORAL DELIVERY OF PEPTIDES AND PROTEINS |
摘要 |
Microfabricated, asymmetrical, reservoir-containing particles for use in the oral delivery of biopolymer therapeutic agents such as peptides, proteins and oligonucleotides are disclosed. The particles are encapsulated in enteric-coated capsules or tablets to provide passage through the stomach and release of a suspension of the particles in the intestinal lumen. The particles have a selected shape, and uniform dimensions preferably in the 100 mu m to 1 mm range. The reservoirs open to the face of the particle and are filled with a therapeutic agent and selected excipients. The excipients are selected to delay the dissolution/release of the agent from the particle reservoirs for 5-60 minutes after the particle is released in the intestinal lumen. Alternatively, the pore is plugged with an erodable material. The face of the particle is grafted with a layer of muco-adhesive ligands designed to quickly bind the particle to the intestinal mucosa for several minutes to several hours after release of the particles from the enteric-coated carrier.
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申请公布号 |
WO0041740(A2) |
申请公布日期 |
2000.07.20 |
申请号 |
WO2000US00362 |
申请日期 |
2000.01.07 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;IMEDD |
发明人 |
GROVE, CARL, F.;DEHLINGER, PETER, J.;FRIEND, DAVID, R.;MARTIN, FRANCIS, J.;FERRARI, MAURO |
分类号 |
C12N15/09;A61K9/14;A61K9/16;A61K9/26;A61K9/48;A61K9/52;A61K31/7088;A61K38/00;A61K38/21;A61K38/22;A61K38/26;A61K38/28;A61K39/395;A61K47/10;A61K47/14;A61K47/22;A61K47/34;A61K47/36;A61K47/38;A61K47/40;A61K47/42;A61K47/44;A61K47/48;A61P35/00;A61P43/00;G03F7/00;(IPC1-7):A61M/ |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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