SPHERONISED SELF-EMULSIFYING SYSTEM FOR HYDROPHOBIC AND WATER-SENSITIVE AGENTS

摘要

A self-emulsifying system which comprises: I) a first portion comprising microcrystalline cellulose; and II) a second portion comprising: (A) up to 200 %, based on the weight of the first portion, of an oily substance; (B) between 2 and 100 %, based on the weight of the first portion, of a surfactant; and (C) between 2 and 1000 %, based on the weight of the oily substance and the surfactants, of water; wherein the total weight of the oily substance and the surfactant is between 2 and 200 % of the first portion, is disclosed, which is particularly useful for providing solid dosage forms of hydrophobic or water sensitive agents when dried or extruded and spheronised.