ANTI-CCR4 ANTIBODIES AND METHODS OF USE THEREFOR

摘要

The present invention relates to an antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 4 (CCR4) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cel l bearing mammalian CCR4 with a ligand thereof, and to use of the antibodies a nd fragments in research, therapeutic, prophylactic and diagnostic methods.