发明名称 |
beta -PHENYLALANINE DERIVATIVES AS INTEGRIN ANTAGONISTS |
摘要 |
The present invention relates to compounds of general formula (1), wherein R<4> is -SO2R<4'>, -COOR<4">, -COR<4'>, -CONR<4'>2 or -CSNR<4'>2; R<4'> is hydrogen, a substituted or unsubstituted alkyl or cycloalkyl residue, a substituted or unsubstituted aryl residue or a saturated or unsaturated, optionally substituted heterocyclic residue; R<4"> is a substituted or unsubstituted alkyl or cycloalkyl residue, a substituted or unsubstituted aryl residue or a saturated or unsaturated, optionally substituted heterocyclic residue; L is a sulphonamide, amide, ether, ester, keto, urea, thioether, sulphoxide or sulphone unit optionally extended by one or two methylene groups; and X is N, O or S; and their physiologically acceptable salts and stereoisomers. The present invention furthermore relates to a process for the preparation of the compounds of formula (1), a pharmaceutical composition containing at least one of these compounds, and the use of compounds of formula (1) for the production of a pharmaceutical composition having integrin-antagonistic action and in particular for the inhibition of angiogenesis and/or for the therapy and prophylaxis of cancer, osteolytic diseases such as osteoporosis, arteriosclerosis, restenosis and ophthalmic disorders.
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申请公布号 |
WO0041469(A2) |
申请公布日期 |
2000.07.20 |
申请号 |
WO2000EP00120 |
申请日期 |
2000.01.11 |
申请人 |
BAYER AKTIENGESELLSCHAFT;SCHOOP, ANDREAS;MUELLER, GERHARD;BRUEGGEMEIER, ULF;SCHMIDT, DELF;STELTE-LUDWIG, BEATRIX;KELDENICH, JOERG;ALBERS, MARKUS |
发明人 |
SCHOOP, ANDREAS;MUELLER, GERHARD;BRUEGGEMEIER, ULF;SCHMIDT, DELF;STELTE-LUDWIG, BEATRIX;KELDENICH, JOERG;ALBERS, MARKUS |
分类号 |
C07D233/50;A61K31/198;A61K31/27;A61K31/4164;A61K31/4184;A61K31/4406;A61K31/4409;A61P9/00;A61P9/10;A61P19/00;A61P19/02;A61P27/02;A61P29/00;A61P35/00;A61P43/00;C07C311/19;C07C311/47;C07D213/40;C07D213/75;C07D235/30;(IPC1-7):C07C311/00 |
主分类号 |
C07D233/50 |
代理机构 |
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地址 |
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