AMINO-DERIVATIVES, METHOD OF INHIBITION OF SYNTHESIS OF NITROGEN OXIDE, METHOD OF SELECTIVE INHIBITION OF SYNTHESIS OF NITROGEN OXIDE PRODUCED BY INDUCIBLE NO-SYNTHASE, METHOD OF DECREASE OF NITROGEN OXIDE LEVEL, PHARMACEUTICAL COMPOSITION

摘要

organic chemistry, biochemistry. SUBSTANCE: invention relates to the novel amino-derivatives of the formula (I) where R1-R4 are hydrogen atoms; X is alkylene with 1-6 carbon atoms; Y is lower alkyl; B means NR5R11 where R5 is hydrogen atom; R11 is taken among 5-6-membered heterocyclic radical where one ring member is carbon and 1-4 members are nitrogen or sulfur heteroatoms, or their pharmaceutically acceptable salts that can be useful as inhibitors of synthesis of nitrogen oxide. Invention proposes also method of inhibition of synthesis of nitrogen oxide, method of selective inhibition of synthesis of nitrogen oxide produced by inducible NO- -synthase, method of decrease of nitrogen oxide level and pharmaceutical composition. EFFECT: improved method of inhibition and decrease of nitrogen oxide level. 6 cl, 1 tbl, 7 ex