ANTISENSE OLIGONUCLEOTIDE COMPOSITIONS TARGETED TO beta 1-ADRENOCEPTOR-SPECIFIC mRNA AND METHODS OF USE

摘要

Disclosed are antisense oligonucleotides specific for mammalian mRNA encoding beta 1-adrenoceptor polypeptides that are useful in the control of hypertension and cardiovascular disease in a mammal. These oligonucleotide compositions provide sustained control of beta 1-adrenoceptor expression over prolonged periods, and achieve therapeutic effects from a single dose. Administration of these antisense compositions to animals resulted in a decrease in blood pressure, but no significant change in heart rate. Use of such antisense compositions in the reduction of beta 1-adrenoceptor polypeptides in a host cell expressing beta 1-adrenoceptor-specific mRNA, and in the preparation of medicaments for treating human and animal diseases, and in particular, hypertension and other cardiac dysfunction is also disclosed.