ACYLATED AMINOALKYLIMIDAZOLES, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION

摘要

organic chemistry, chemical technology, pharmacy. SUBSTANCE: invention describes acylated aminoalkylimidazoles of the general formula (I) where R1 means phenyl group possibly monosubstituted with halogen atom or 1-naphthyl group; R2 means hydrogen atom; or R1 is hydrogen atom and R2 is pyridyl or 2-(5-chloro)-pyridyl group; R3 is halogen atom or C1-4-alkoxy-group. Described compounds can be in free form or in the form of salts. Compounds of the formula (I) show capability to inhibit activity of 25-hydroxy-vitamin D3 hydroxylase selectively. Invention describes also method of their synthesis and pharmaceutical composition based on compound of the formula (I). EFFECT: improved method of synthesis, valuable biochemical properties of compounds. 6 cl, 12 ex