发明名称 |
POLYMERIC FLUOROPHORES ENHANCED BY MOIETIES PROVIDING A HYDROPHOBIC AND CONFORMATIONALLY RESTRICTIVE MICROENVIRONMENT |
摘要 |
<p>Fluorescent conjugates suitable for use in flow cytometry and other biological applications. The fluorescent conjugates comprise an antibody having a polymeric dye bound thereto. The polymeric dye is preferably enhanced by a hydrophobic and conformationally restrictive moiety either bound thereto or in close association therewith. The hydrophobic and conformationally restrictive moiety is preferably derived from a cyclodextrin. The polymeric dye comprises a polymeric entity having signal-generating groups, such as aminostyryl pyridinium dye residues attached thereto. The fluorescent conjugates exhibit exceptional stability characteristics and avoid many of the problems of energy transfer, bio-conjugability, and solubility.</p> |
申请公布号 |
EP1019722(A1) |
申请公布日期 |
2000.07.19 |
申请号 |
EP19970904060 |
申请日期 |
1997.01.30 |
申请人 |
ABBOTT LABORATORIES |
发明人 |
BIENIARZ, CHRISTOPHER;HUFF, JEFFREY, B.;CORNWELL, MICHAEL, J.;TATA VENKATA, SESHAGIRI, R. |
分类号 |
C09B69/10;G01N21/78;G01N33/533;(IPC1-7):G01N33/533 |
主分类号 |
C09B69/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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