Human antibodies that bind human TNF alpha

摘要

Human antibodies, preferably recombinant human antibodies, that specifically bind to human tumor necrosis factor alpha (hTNF alpha ) are disclosed. These antibodies have high affinity for hTNF alpha (e.g., Kd=10-8 M or less), a slow off rate for hTNF alpha dissociation (e.g., Koff=10-3 sec-1 or less) and neutralize hTNF alpha activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hTNF alpha and for inhibiting hTNF alpha activity, e.g., in a human subject suffering from a disorder in which hTNF alpha activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention.