Thiophene derivative and pharmaceutical composition thereof

摘要

PCT No. PCT/JP97/02255 Sec. 371 Date Dec. 30, 1998 Sec. 102(e) Date Dec. 30, 1998 PCT Filed Jun. 30, 1997 PCT Pub. No. WO98/00420 PCT Pub. Date Jan. 8, 1998Thiophene derivatives represented by the following general formula (I) or pharmaceutically acceptable salts thereof. Said compounds act as an anti-PCP agonist and therefore are useful as psychotropic or antischizophrenic agents and so on. (In the above formula, R1 is a formula -A1-X1-R3; R2 is a formula -A2-X2-R4 or does not exist; B ring is a 7- to 10-membered nitrogen-containing cycloalkyl ring; Ar ring is an aryl or heteroaryl ring; A1, A2 and A3 may be the same or different from one another and each represents a bond or a lower alkylene group; X1 and X2 may be the same or different from each other and each represents a bond or a formula -O-, -S-or the like; R3 and R4 may be the same or different from each other and each represents a hydrogen atom, a cyclic imido group or a lower alkyl group, a cycloalkyl group, an aryl group or an aralkyl group; with the proviso that, when Ar ring is thiazole ring, either one of A1 and A2 is a lower alkylene group. Also, when Ar ring is a benzene ring, a case in which one of R1 and R2 is methyl group or a halogen group and the other is a hydrogen atom is excluded.)