NUCLEAR FACTOR KAPPA B ACTIVATION INHIBITOR TARGETING TAK1, AND IDENTIFICATION THEREOF

摘要

PROBLEM TO BE SOLVED: To identify or screening NF-κB activation inhibitor usable for treatment or the like of autoimmune disease by examining the modulating activities of a specimen to the function of TGF-β activated kinase 1(TAK1). SOLUTION: NF-κB(Nuclear Factor kappa B) activation inhibitor useful as a therapeutic agent, prophylactic or the like of autoimmune disease or intractable disease providing inflammatory symptom is identified or screened by examining the modulating activities of a specimen to the function of the TAK1. Preferably, the function of the TAK1 is the one selected from the interaction of the TAK1 and a TAK1-binding protein 1, activation of IKK complex by the TAK1 in a cell, the NF-κB activation induced by the TAK1, and the like.