发明名称 |
Method of preparation of known and novel 2'-modified nucleosides by intramolecular nucleophilic displacement |
摘要 |
PCT No. PCT/US95/06641 Sec. 371 Date Oct. 30, 1996 Sec. 102(e) Date Oct. 30, 1996 PCT Filed May 25, 1995 PCT Pub. No. WO95/35102 PCT Pub. Date Dec. 28, 1995A method for the preparation of 2'-modified nucleosides is provided. The method comprises a novel intramolecular nucleophilic displacement reaction. Included in the invention are novel 2'-modified pyrimidines and purines prepared according to the method of the invention, novel pyrimidines and purines bearing a 2',3' heterocyclic substituent and oligonucleotides containing said 2'-modified pyrimidines and purines. The 2'-modified nucleosides are useful as anti-viral and anti-neoplastic agents.
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申请公布号 |
US6090932(A) |
申请公布日期 |
2000.07.18 |
申请号 |
US19960732283 |
申请日期 |
1996.10.30 |
申请人 |
PROLIGO LLC |
发明人 |
MCGEE, DANNY P.;PIEKEN, WOLFGANG A.;SEBESTA, DAVID P.;ZHAI, YANSHENG |
分类号 |
C07H9/06;A61K31/70;A61K31/7042;A61K31/7052;A61K31/7064;A61K31/7072;A61K31/7076;A61P31/12;A61P35/00;C07H19/06;C07H19/067;C07H19/073;C07H19/10;C07H19/16;C07H19/167;C07H19/173;C07H19/20;C07H21/00;(IPC1-7):C07H21/04;C07H19/00;C07D487/00 |
主分类号 |
C07H9/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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