发明名称 |
Stimulation of an immune response with antibodies labeled with the alpha -galactosyl epitope |
摘要 |
Humoral and cellular immune responses against tumor cells and infectious agents are induced in a mammal using an antibody that binds with an epitope of an antigen that is associated with a tumor or an infectious agent, and that contains at least one alpha -galactosyl epitope. Such an antibody is capable of forming a complex with cells that express the target epitope and with antibodies that bind alpha -galactosyl epitopes. Suitable antibodies include molecules that contain at least one engineered glycosylation site in the constant region of the heavy chain.
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申请公布号 |
US6090381(A) |
申请公布日期 |
2000.07.18 |
申请号 |
US19980020299 |
申请日期 |
1998.02.06 |
申请人 |
IMMUNOMEDICS, INC. |
发明人 |
LEUNG, SHUI-ON;QU, ZHENGXING |
分类号 |
C12N15/09;A61K38/00;A61K39/00;A61K39/395;A61K47/48;A61P37/04;A61P43/00;C03C17/245;C03C17/34;C07K16/28;C07K16/30;C07K16/42;C07K19/00;C12P21/08;C23C14/10;C23C14/34;(IPC1-7):A61K39/395 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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