| 摘要 |
PROBLEM TO BE SOLVED: To obtain the subject new derivative excellent in suppressing action on a specific interleukin production, and useful as a preventing and treating agent for an immune system disease, an inflammatory disease, an ischemic disease, or the like. SOLUTION: This new piridazine derivative is a compound of formula I [R1 is a (substituted) aryl; R2 is a phenyl substituted at least with a lower alkoxy or the like at its 4 position and other positions thereof are substitutable; R3 is H or the like; A is a single bond or the like; X is O or the like; a broken line is a single bond or the like; provided that such conditions must be satisfied when the R3 is a halogenated lower alkyl, the A is a single bond, or the like], preferably 5,6-bis(4-methoxyphenyl)-2-(4-chlorocinnamyl)-2H-piridazin-3-one, or the like. The compound of formula I is obtained e.g. by reacting a compound of formula II with glyoxalic acid, reacting a hydrated hydrazine with the obtained compound, then performing dehydration reaction, and then reacting the obtained compound of formula III with a compound of the formula: R3-A-Y (Y is a halogen). The obtained compound has an interleukin-1βproduction- suppressing activity.
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