发明名称 |
Small particle liposome aerosols for delivery of anti-cancer drugs |
摘要 |
The small particle liposome or lipid complex aerosol compounds and methods of treatment of the present invention involve lipid- or water soluble anti-cancer drugs incorporated into liposomes or other lipid complexes. The liposomes and complexes are administered in aqueous dispersions from a jet nebulizer to the respiratory tract of an individual. Various anti-cancer drugs may be used, including 20-S-Camptothecin, 9-Nitro-camptothecin, 9-Amino-camptothecin, 10, 11-methylenedioxy-camptothecin and taxol or its derivatives. Administration of these drugs by inhalation provides faster and more efficient absorption of the anticancer drug than does intramuscular administration or oral administration.
|
申请公布号 |
US6090407(A) |
申请公布日期 |
2000.07.18 |
申请号 |
US19970933254 |
申请日期 |
1997.09.23 |
申请人 |
RESEARCH DEVELOPMENT FOUNDATION |
发明人 |
KNIGHT, J. VERNON;GILBERT, BRIAN;WALDREP, J. CLIFFORD;KOSHKINA, NADEZHDA |
分类号 |
A61K9/00;A61K9/12;A61K9/127;A61K31/03;A61K31/175;A61K31/337;A61K31/437;A61K31/4745;A61K31/505;A61K31/513;A61K31/519;A61K31/52;A61K31/525;A61K31/7048;A61K38/21;A61K45/00;A61P35/00;(IPC1-7):A61K9/127 |
主分类号 |
A61K9/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|