发明名称 Use of an NADPH-oxidase inhibitor in the treatment of reperfusion injury
摘要 The present invention is directed to a method for the prophylactic and therapeutic treatment of reperfusion injury or injury due to a distal reperfusion. The method involves the administration of an NADPH-oxidase inhibitor to a cell, tissue, organ or animal in an amount sufficient to treat the cell, tissue, organ or animal for reperfusion injury prophylactically or therapeutically. The NADPH-oxidase inhibitor preferably is an o-methoxycatechol, or a pharmaceutically acceptable salt, derivative, dimer or prodrug thereof. Most preferably, the o-methoxycatechol is apocynin.
申请公布号 US6090851(A) 申请公布日期 2000.07.18
申请号 US19980150069 申请日期 1998.09.09
申请人 JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE 发明人 DODD-O, JEFFREY M.;PEARSE, DAVID B.
分类号 A61K31/00;A61K31/12;(IPC1-7):A61K31/19;A61K31/11;A61K31/075;A61K31/05 主分类号 A61K31/00
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