Substituted N-carboxyalkylpeptidyl derivatives as antidegenerative agents

摘要

Novel N-carboxyalkylpeptidyl compounds represented by the formula which are found to be useful inhibitors of matrix metalloendoproteinases which degrade major components of articular cartilage and basement membranes causing degenerative diseases such as arthritis, periodontal disease, corneal ulceration and the like, and certain cancers, are described.