Phenylpyridine derivatives useful as phosphodiesterase inhibitors

摘要

PCT No. PCT/EP97/01157 Sec. 371 Date Sep. 1, 1998 Sec. 102(e) Date Sep. 1, 1998 PCT Filed Mar. 7, 1997 PCT Pub. No. WO97/32853 PCT Pub. Date Sep. 12, 1997(4-oxy-3-(aryl)phenyl)pyridine compounds, in free or acid addition salt form, are useful as pharmaceuticals for treatment and prophylaxis of inflammation, particularly inflammatory or obstructive diseases of the airways, e.g. for asthma therapy. Preferred compounds are novel biphenyl pyridines, biphenyl benzamides and biphenyl phenylcarboxy compounds. The compounds are selective inhibitors of PDE 4 isoenzyme activity and also act to down regulate or inhibit TNF- alpha release.