Inhibitors of farnesyl-protein transferase

摘要

PCT No. PCT/US97/01600 Sec. 371 Date Jul. 27, 1998 Sec. 102(e) Date Jul. 27, 1998 PCT Filed Jan. 27, 1997 PCT Pub. No. WO97/27854 PCT Pub. Date Aug. 7, 1997The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods of inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.