发明名称 Reversible hydrogels
摘要 The invention is based on the discovery that a block copolymer that includes alpha -helical blocks, e.g., terminal blocks, which form intermolecular coiled-coil structures, and one or more random-coil blocks, which link the alpha -helical blocks, can form suspensions that can reversibly gel to form monodisperse hydrogels. The transition between the gel and liquid phases depends on pH, temperature, concentration, and chemical structure. The copolymers can be synthesized biologically through genetic engineering.
申请公布号 US6090911(A) 申请公布日期 2000.07.18
申请号 US19970956307 申请日期 1997.10.22
申请人 UNIVERSITY OF MASSACHUSETTS 发明人 PETKA, WENDY A.;TIRRELL, DAVID A.;MCGRATH, KEVIN P.
分类号 A61L15/32;A61L15/60;A61L26/00;C12P21/02;(IPC1-7):C07K14/00;A61K31/74;A61K38/00 主分类号 A61L15/32
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