Quinazolinone-containing pharmaceutical compositions for prevention of neovascularization

摘要

PCT No. PCT/US96/13210 Sec. 371 Date May 26, 1998 Sec. 102(e) Date May 26, 1998 PCT Filed Aug. 12, 1996 PCT Pub. No. WO97/06805 PCT Pub. Date Feb. 27, 1997The invention provides a composition for attenuating neovascularization comprising administering a pharmaceutically effective amount of a compound of formula I: wherein: n=1 or 2; R1 is a member of the group consisting of hydrogen, halogen, nitro, benzo, lower alkyl, phenyl and lower alkoxy; R2 is a member of the group consisting of hydroxy, acetoxy, and lower alkoxy, and R3 is a member of the group consisting of hydrogen and lower alkenoxy-carbonyl; as an active ingredient therein, in combination with a pharmaceutically acceptable carrier.