Tricykliske forbindelser, deres fremstilling, deres anvendelse ved fremstillingen af colchicin og thiocolchicin, som er opt

摘要

Tricyclic cpds. of formula (I) are new. (a) R1, R2 = alkyl and R3 = H or A-SO2; (b) R2, R3 = both H or both alkyl and R1 = A-SO2-; (c) R1-R3 = all H or all alkyl; (d) R1 = A-SO2- or H and OR2+OR3 = -O-X-O-; (e) R3 = A-SO2-; OR2+OR3 = -O-X-O-; (f) R1 = H and R2, R3 = both alkyl or OR2+OR3 = -O-X-O-; A = alkyl, phenyl (opt. substd. by 1-3 alkyl) or naphthyl (opt. substd. by 1-5 alkyl); alkyl and alkyloxy = 1-6C; X = -B(OR4)-, alkyl, -C(O)- or -CR5R6-; R4 = H; R5, R6 = H, alkyl or phenyl (opt. substd. by 1-3 alkyl, hydroxy or alkoxy); or CR5R6 = 5 or 6 membered carbocycle.