ASPARTIC PROTEASE INHIBITORS

摘要

The present invention provides a compound of formula (I) wherein a, b, c, d, and e, are R<7>, OR<7>, SR<7>, NR<7>R<8>, NHCOR<7>, CO2R<7>, CN, NO2, NH2, N3, or a halogen. R<7> and R<8> are H or alkyl, R<1> and R<2> are H or alkyl, and R<3> is a non-aromatic substituent. Substituent A is OH, NH2, or SH. Substituents B and B<1> include amide and sulfonamide groups, which can be cyclic, acyclic, or amino acid derivatives. Alternatively, B and R' together with the nitrogen to which they are bonded, and/or B' and R<2> together with the nitrogen to which they are bonded, define a heterocycle. The present invention further provides a pharmaceutical composition that includes a carrier and a therapeutically effective amount of at least one compound of the present invention. The present invention further provides therapeutic methods that include administering a therapeutically effective amount of at least one compound of the present invention.