NOVEL NITROPHENYLAZIRIDINE COMPOUNDS AND THEIR USE AS PRODRUGS
摘要
A range of aziridin-1-yl nitrobenzamides (A-C) are provided for use as prodrugs in conjunction with nitroreductase (NR) enzymes. The amides may have 1 or 2 N-substituents which may be bulky and polar. For example, 5-(aziridin-1-yl) -N-[2-(4-morpholino) ethyl] -2,4-dinitrobenzamide of Compound (1) was found to be highly active against all NR+ cell lines tested.
申请公布号
WO0013683(A3)
申请公布日期
2000.07.13
申请号
WO1999GB02956
申请日期
1999.09.07
申请人
CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED;DENNY, WILLIAM, ALEXANDER;ATWELL, GRAHAM, JOHN;PALMER, BRIAN, DESMOND;WILSON, WILLIAM, ROBERT
发明人
DENNY, WILLIAM, ALEXANDER;ATWELL, GRAHAM, JOHN;PALMER, BRIAN, DESMOND;WILSON, WILLIAM, ROBERT