METHODS FOR TREATING CONDITIONS ASSOCIATED WITH THE ACCUMULATION OF EXCESS EXTRACELLULAR MATRIX
摘要
The present invention is methods and compositions for reducing and preventing the excess accumulation of extracellular matrix in a tissue and/or organ or at a wound site using a combination of agents that inhibit TGF beta , or using agents that inhibit TGF beta in combination with agents that degrade excess accumulated extracellular matrix. The compositions and methods of the invention are used to treat conditions such as fibrotic diseases and scarring that result from excess accumulation of extracellular matrix, impairing tissue or organ function or skin appearance in a suject.
申请公布号
WO0040227(A2)
申请公布日期
2000.07.13
申请号
WO2000US00179
申请日期
2000.01.05
申请人
UNIVERSITY OF UTAH;AMERICAN NATIONAL RED CROSS;NOBLE, NANCY, A.;BORDER, WAYNE, A.;LAWRENCE, DANIEL, A.
发明人
NOBLE, NANCY, A.;BORDER, WAYNE, A.;LAWRENCE, DANIEL, A.