PREPARATION OF MICROPARTICLES HAVING A SELECTED RELEASE PROFILE

摘要

An improved method for preparing microparticles that exhibit controlled release of an effective amount of an active agent over an extended period of time. More particularly, a method is provided for preparing microparticles having a selected release profile for release of active agent contained in t he microparticles. By adjusting the degree of drying that is performed during t he preparation of the microparticles, the release profile can be controlled. By performing no intermediate drying, an initial burst and a substantially line ar release profile is achieved. By performing substantially complete intermedia te drying, an initial lag phase and a substantially sigmoidal release profile i s achieved.